Structure of PDB 4a50 Chain A

Receptor sequence
>4a50A (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTY
TFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTME
GERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNE
ELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK
GAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDL
AGSENININQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRT
SIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
3D structure
PDB4a50 Triphenylbutanamines: Kinesin Spindle Protein Inhibitors with in Vivo Antitumor Activity.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R24 R26 P27 G108 G110 K111 T112 F113 E118 R8 R10 P11 G92 G94 K95 T96 F97 E102
BS02 DQ6 A E116 G117 E118 R119 I136 P137 Y211 E215 R221 E100 G101 E102 R103 I120 P121 Y195 E199 R205 PDBbind-CN: -logKd/Ki=7.91,Ki=12.2nM
BindingDB: Ki=11.1nM
BS03 DQ7 A E116 G117 E118 R119 A133 P137 Y211 L214 E215 E100 G101 E102 R103 A117 P121 Y195 L198 E199 BindingDB: Ki=10.2nM,EC50=73nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:4a50, PDBe:4a50, PDBj:4a50
PDBsum4a50
PubMed22248262
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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