Structure of PDB 4a36 Chain A

Receptor sequence

>4a36A (length=523) Species: 8839 (Anas platyrhynchos)

KKARSYQIELAQPAINGKNALICAPTGSGKTFVSILICEHHFQNMPAGRK
AKVVFLATKVPVYEQQKNVFKHHFERQGYSVQGISGENFSNVSVEKVIED
SDIIVVTPQILVNSFEDGTLTSLSIFTLMIFDECHNTTGNHPYNVLMTRY
LEQKFNSASQLPQILGLTASVGVGNAKNIEETIEHICSLCSYLDIQAIST
VRENIQELQRFMNKPEIDVRLVKRRIHNPFAAIISNLMSETEALMRTIFG
TQNYEHWIVVTQRKCREEESRICRALFICTEHLRKYNDALIISEDARIID
ALSYLTEFFTNVKNGPYTELEQHLTAKFQEKEPELIALSKDETNENPKLE
ELVCILDDAYRYNPQTRTLLFAKTRALVSALKKCMEENPILNYIKPGVLM
GRGMTLPSQKGVLDAFKTSKDNRLLIATSVADEGIDIVQCNLVVLYEYSG
NVTKMIQVRGRGRAAGSKCILVTSKTEVVENEKCNRYKEEMMNKAVEKIQ
KWDEETFAKKIHNLQMKERVLRD

3D structure

• PDB: 4a36 Structural Basis for the Activation of Innate Immune Pattern Recognition Receptor Rig-I by Viral RNA.
• Chain: A
• Resolution: 3.7 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	G382 N383 H384 Q508 N509	G139 N140 H141 Q252 N253
BS02	rna	A	K302 V303 G329 T350 Q352 N356 H512 R519 K636 T637 R638 T698 S699 V700	K59 V60 G86 T107 Q109 N113 H256 R263 K373 T374 R375 T428 S429 V430
BS03	ADP	A	K244 K245 R247 Q250 G270 G272 K273 T274 F275 D706 R733	K1 K2 R4 Q7 G27 G29 K30 T31 F32 D436 R463
BS04	AF3	A	K273 E376 G704 R731 R733	K30 E133 G434 R461 R463

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:4a36, PDBe:4a36, PDBj:4a36
• PDBsum: 4a36
• PubMed: 22000019
• UniProt: D3TI84