Structure of PDB 4a2c Chain A

Receptor sequence

>4a2cA (length=346) Species: 83333 (Escherichia coli K-12)

MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLPRIFKNGA
HYYPITLGHEFSGYIDAVGSGVDDLHPGDAVACVPLLPCFTCPECLKGFY
SQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTDMPIEDGAFIEPITVGL
HAFHLAQGCENKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDISSEKLAL
AKSFGAMQTFNSSEMSAPQMQSVLRELRFNQLILETAGVPQTVELAVEIA
GPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWE
TASRLLTERKLSLEPLIAHRGSFESFAQAVRDIARNAMPGKVLLIP

3D structure

• PDB: 4a2c The Crystal Structure of Galactitol-1-Phosphate 5-Dehydrogenase from Escherichia Coli K12 Provides Insights Into its Anomalous Behavior on Imac Processes
• Chain: A
• Resolution: 1.87 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C38 G39 S40 P43 H59 E60 C89 C92 C95 C103 D107 P145 G149 K341
• Catalytic site (residue number reindexed from 1): C38 G39 S40 P43 H59 E60 C89 C92 C95 C103 D107 P145 G149 K341
• Enzyme Commision number: 1.1.1.251: galactitol-1-phosphate 5-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C89 C92 C95 C103	C89 C92 C95 C103

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0008868 galactitol-1-phosphate 5-dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0042802 identical protein binding
• GO:0042803 protein homodimerization activity
• GO:0046872 metal ion binding

Biological Process

• GO:0019402 galactitol metabolic process
• GO:0019404 galactitol catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:4a2c, PDBe:4a2c, PDBj:4a2c
• PDBsum: 4a2c
• PubMed: 22979983
• UniProt: P0A9S3|GATD_ECOLI Galactitol 1-phosphate 5-dehydrogenase (Gene Name=gatD)