Structure of PDB 4a28 Chain A

Receptor sequence
>4a28A (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
GKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKT
YTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTM
EGERSEEDPLDGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLL
NPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRT
TAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSERA
REAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSI
IATISPASLNLEETLSTLEYAHRAKNILNKPE
3D structure
PDB4a28 The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R24 G108 G110 K111 T112 F113 R9 G93 G95 K96 T97 F98
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:4a28, PDBe:4a28, PDBj:4a28
PDBsum4a28
PubMed23875972
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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