Structure of PDB 4a1t Chain A

Receptor sequence
>4a1tA (length=193) [Search protein sequence]
GSVVIVGRIILSPITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTA
TQSFLATCVNGVCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPP
GARSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSS
GGPLLCPSGHAVGIFRAAVCTRGVAKAVDFVPVESMETTMRGS
3D structure
PDB4a1t High Affinity Peptide Inhibitors of the Hepatitis C Virus Ns3-4A Protease Refractory to Common Resistant Mutants.
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H68 D92 G148 S150
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V-9 S7 Q9 L13 S37 A39 Q41 S42 H57 R109 V132 L135 K136 G137 S139 F154 R155 A156 A157 V158 C159 V6 S18 Q20 L24 S48 A50 Q52 S53 H68 R120 V143 L146 K147 G148 S150 F165 R166 A167 A168 V169 C170
BS02 ZN A C97 C99 C145 C108 C110 C156
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:4a1t, PDBe:4a1t, PDBj:4a1t
PDBsum4a1t
PubMed22965230
UniProtP26662|POLG_HCVJA Genome polyprotein

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