Structure of PDB 4a1g Chain A

Receptor sequence
>4a1gA (length=146) Species: 9606 (Homo sapiens) [Search protein sequence]
DTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEH
LMKEFLDKKKYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPL
YIAWAGHLEAQGELQHASAVLQRGIQNQAEPREFLQQQYRLFQTRL
3D structure
PDB4a1g Structural Analysis Reveals Features of the Spindle Checkpoint Kinase Bub1-Kinetochore Subunit Knl1 Interaction.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E50 F75 Y78 N79 S80 D81 Q84 F88 E49 F74 Y77 N78 S79 D80 Q83 F87
BS02 peptide A E87 H117 E86 H116
Gene Ontology
Biological Process
GO:0007094 mitotic spindle assembly checkpoint signaling

View graph for
Biological Process
External links
PDB RCSB:4a1g, PDBe:4a1g, PDBj:4a1g
PDBsum4a1g
PubMed22331848
UniProtO43683|BUB1_HUMAN Mitotic checkpoint serine/threonine-protein kinase BUB1 (Gene Name=BUB1)

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