Structure of PDB 4a15 Chain A

Receptor sequence
>4a15A (length=596) Species: 2303 (Thermoplasma acidophilum) [Search protein sequence]
RQYQVEAIDFLRSSLQKSYGVALESPTGSGKTIMALKSALQYSSERKLKV
LYLVRTNSQEEQVIKELRSLSSTMKIRAIPMQGRVNMCILYRMVDDLHEI
NAESLAKFCNMKKREVMAGNEAACPYFNFKIRSDETKRFLFDELPTAEEF
YDYGERNNVCPYESMKAALPDADIVIAPYAYFLNRSVAEKFLSHWGVSRN
QIVIILDEAHNLPDIGRSIGSFRISVESLNRADREAQAYGDPELSQKIHV
SDLIEMIRSALQSMVSERCGKGDVRIRFQEFMEYMRIMNKRSEREIRSLL
NYLYLFGEYVENEKEKVGKVPFSYCSSVASRIIAFSDQDEEKYAAILSPE
DGGYMQAACLDPSGILEVLKESKTIHMSGTLDPFDFYSDITGFEIPFKKI
GEIFPPENRYIAYYDGVDEKELDRMATVIEDIILKVKKNTIVYFPSYSLM
DRVENRVSFEHMKEYRGIDQKELYSMLKKFRRDHGTIFAVSGGRLNELEM
IILAGLPFPRPDAINRSLFDYYERKYGKGWEYSVVYPTAIKIRQEIGRLI
RSAEDTGACVILDKRAGQFRKFIPDMKKTSDPASDIYNFFISAQAR
3D structure
PDB4a15 Functional and Structural Studies of the Nucleotide Excision Repair Helicase Xpd Suggest a Polarity for DNA Translocation.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F527 P528 P530 W549 R584 F508 P509 P511 W530 R565
BS02 SF4 A R88 C92 L94 C113 C128 C164 R84 C88 L90 C109 C124 C160
BS03 CA A E312 E315 E308 E311
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006281 DNA repair
GO:0032508 DNA duplex unwinding

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Molecular Function
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Biological Process
External links
PDB RCSB:4a15, PDBe:4a15, PDBj:4a15
PDBsum4a15
PubMed22081108
UniProtQ9HM14|XPD_THEAC ATP-dependent DNA helicase XPD (Gene Name=Ta0057)

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