Structure of PDB 4a12 Chain A

Receptor sequence
>4a12A (length=183) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
KLKKDKRREAIRQQIDSNPFITDHELSDLFQVSIQTIRLDRTYLNIPELR
KRIKLVAEKNYDQISSIEEQEFIGDLIQVNPNVKAQSILDITSDSVFHKT
GIARGHVLFAQANSLCVALIKQPTVLTHESSIQFIEKVKLNDTVRAEARV
VNQTAKHYYVEVKSYVKHTLVFKGNFKMFYDKR
3D structure
PDB4a12 Structural Basis for Feed-Forward Transcriptional Regulation of Membrane Lipid Homeostasis in Staphylococcus Aureus.
ChainA
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D29 R44 R47 E54 L55 R56 D23 R38 R41 E48 L49 R50 PDBbind-CN: Kd=0.5nM
BS02 dna A R13 V38 S39 Q41 T42 R7 V32 S33 Q35 T36 PDBbind-CN: Kd=0.5nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0045892 negative regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4a12, PDBe:4a12, PDBj:4a12
PDBsum4a12
PubMed23300457
UniProtQ2FZ56

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