Structure of PDB 4a0k Chain A

Receptor sequence
>4a0kA (length=719) Species: 9606 (Homo sapiens) [Search protein sequence]
KKLVIKNFRDRPRLPDNYTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAV
ENLCSHKVSPMLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQ
DHCRQMIMIRSIFLFLDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQS
KTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKFLEETN
CLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACV
EKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW
SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLM
KESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILF
RFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK
LEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPME
VHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQ
VSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI
KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQ
DRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLI
DRDYMERDKDNPNQYHYVA
3D structure
PDB4a0k The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation.
ChainA
Resolution5.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0061630 ubiquitin protein ligase activity
GO:0160072 ubiquitin ligase complex scaffold activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001701 in utero embryonic development
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 DNA damage response
GO:0007283 spermatogenesis
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0016567 protein ubiquitination
GO:0030097 hemopoiesis
GO:0030853 negative regulation of granulocyte differentiation
GO:0034644 cellular response to UV
GO:0035019 somatic stem cell population maintenance
GO:0042110 T cell activation
GO:0042254 ribosome biogenesis
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0048511 rhythmic process
GO:0051246 regulation of protein metabolic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:2000001 regulation of DNA damage checkpoint
GO:2000819 regulation of nucleotide-excision repair
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0080008 Cul4-RING E3 ubiquitin ligase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4a0k, PDBe:4a0k, PDBj:4a0k
PDBsum4a0k
PubMed22118460
UniProtQ13619|CUL4A_HUMAN Cullin-4A (Gene Name=CUL4A)

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