Structure of PDB 3zyu Chain A

Receptor sequence
>3zyuA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB3zyu Inhibition of Bet Recruitment to Chromatin as an Effective Treatment for Mll-Fusion Leukaemia.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1GH A W81 P82 F83 L92 Y139 I146 M149 W40 P41 F42 L51 Y98 I105 M108 MOAD: ic50=0.1uM
PDBbind-CN: -logKd/Ki=7.00,Kd=0.1uM
BindingDB: IC50=790nM,Ki=9.0nM,Kd=53nM
External links
PDB RCSB:3zyu, PDBe:3zyu, PDBj:3zyu
PDBsum3zyu
PubMed21964340
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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