Structure of PDB 3zy2 Chain A

Receptor sequence
>3zy2A (length=342) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
ATDPNGYIVFCPCMGRFGNQVDQFLGVLAFAKALDRTLVLPNFIEFKHPE
TKMIPFEFLFQVGTVAKYTRVVTMQEFTKKIMPTVWPPEKRKAFCWTPRQ
EPGCHSKEGNPFGPYWDQIDVSFVGDEYFGDIPGGFDLKWLEKFPSEEYP
VLAFSSAPAPFPSKGKVWSIQKYLRWSSRITEQAKKFISANLAKPFVAVH
LRNDADWVRVCEHIDTTTNRPLFASEQCLGEGHHLGTLTKEICSPSKQQI
LEQIVEKVGSIGAKSVFVASDKDHMIDEINEALKPYEIEAHRQEPDDMYT
SLAIMGRADLFVGNCVSTFSHIVKRERDHAGQSPRPSAFFGI
3D structure
PDB3zy2 Structural Insights Into the Mechanism of Protein O-Fucosylation.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.221: peptide-O-fucosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A R40 F41 G42 N43 H238 R240 A307 S308 D309 D334 M336 S355 T356 F357 R16 F17 G18 N19 H200 R202 A269 S270 D271 D296 M298 S317 T318 F319 MOAD: Kd=0.35uM
PDBbind-CN: -logKd/Ki=6.46,Kd=0.35uM
Gene Ontology
Molecular Function
GO:0008417 fucosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046922 peptide-O-fucosyltransferase activity
Biological Process
GO:0006004 fucose metabolic process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0007219 Notch signaling pathway
GO:0036066 protein O-linked fucosylation
Cellular Component
GO:0005783 endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zy2, PDBe:3zy2, PDBj:3zy2
PDBsum3zy2
PubMed21966509
UniProtQ18014|OFUT1_CAEEL GDP-fucose protein O-fucosyltransferase 1 (Gene Name=pfut-1)

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