Structure of PDB 3zwf Chain A

Receptor sequence
>3zwfA (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
MDVTFLGTGAAYPSPTRGASAVVLRCEGECWLFDCGEGTQTQLMKSQLKA
GRITKIFITHLHGDHFFGLPGLLCTISLQSQPIEIYGPVGLRDFIWRTME
LSHTELVFHYVVHELVPTADQCPAQGRTILLDSEENSYLLFDDEQFVVKA
FRLFHRIPSFGFSVVEKKVGRKICILGDCSGVVGDGGVKLCFEADLLIHE
ATLDDAQMDKAKEHGHSTPQMAATFAKLCRAKRLVLTHFSQRYQEVTLAE
DFMVISIPI
3D structure
PDB3zwf Crystal Structure of Human Trnase Z, Short Form (Elac1).
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.11: ribonuclease Z.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D66 H67 D253 H313 D64 H65 D178 H238
BS02 ZN A H62 H64 H182 D253 H60 H62 H155 D178
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004549 tRNA-specific ribonuclease activity
GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters
GO:0042781 3'-tRNA processing endoribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0008033 tRNA processing
GO:0042780 tRNA 3'-end processing
GO:0072344 rescue of stalled ribosome
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zwf, PDBe:3zwf, PDBj:3zwf
PDBsum3zwf
PubMed
UniProtQ9H777|RNZ1_HUMAN Zinc phosphodiesterase ELAC protein 1 (Gene Name=ELAC1)

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