Structure of PDB 3zvm Chain A

Receptor sequence
>3zvmA (length=380) Species: 10090 (Mus musculus) [Search protein sequence]
SLGWESLKKLLVFTASGVKPQGKVAAFDLDGTLITTRSGKVFPTSPSDWR
ILYPEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEKL
GVPFQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAGR
LANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDP
RTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVH
VNRDTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGV
PCRCFNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAE
GFLEILEIPFRLQEHLDPALQRLYRQFSEG
3D structure
PDB3zvm The structural basis for substrate recognition by mammalian polynucleotide kinase 3' phosphatase.
ChainA
Resolution1.997 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.78: polynucleotide 5'-hydroxyl-kinase.
3.1.3.32: polynucleotide 3'-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D172 F184 N217 M219 G220 R258 F305 D30 F42 N75 M77 G78 R116 F163
BS02 ADP A G374 G376 K377 S378 T379 N459 R463 F502 L504 Q505 G232 G234 K235 S236 T237 N317 R321 F360 L362 Q363
BS03 MG A D170 D172 D288 D28 D30 D146
BS04 MG A S378 D396 S236 D254
Gene Ontology
Molecular Function
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3zvm, PDBe:3zvm, PDBj:3zvm
PDBsum3zvm
PubMed22055185
UniProtQ9JLV6|PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase (Gene Name=Pnkp)

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