Structure of PDB 3zvf Chain A

Receptor sequence
>3zvfA (length=188) Species: 42789 (enterovirus D68) [Search protein sequence]
GPGFDFAQAIMKKNTVVARTEKGEFTMLGVHDRVAVIPTHASVGETIYIN
DVETKVLDACALRDLTDTNLEITIVKLDRNQKFRDIRHFLPRYEDDYNDA
VLSVHTSKFPNMYIPVGQVTNYGFLNLGGTPTHRILMYNFPTRAGQCGGV
VTTTGKVIGIHVGGNGAQGFAAMLLHSYFTDTQKHHHH
3D structure
PDB3zvf 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H40 E71 G145 C147
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G85 A H40 N126 G128 T142 R143 A144 C147 H161 V162 G163 G164 N165 H40 N126 G128 T142 R143 A144 C147 H161 V162 G163 G164 N165
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3zvf, PDBe:3zvf, PDBj:3zvf
PDBsum3zvf
PubMed23388726
UniProtA1E4A3

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