Structure of PDB 3zve Chain A

Receptor sequence
>3zveA (length=188) Species: 42789 (enterovirus D68) [Search protein sequence]
GPGFDFAQAIMKKNTVVARTEKGEFTMLGVHDRVAVIPTHASVGETIYIN
DVETKVLDACALRDLTDTNLEITIVKLDRNQKFRDIRHFLPRYEDDYNDA
VLSVHTSKFPNMYIPVGQVTNYGFLNLGGTPTHRILMYNFPTRAGQCGGV
VTTTGKVIGIHVGGNGAQGFAAMLLHSYFTDTQKHHHH
3D structure
PDB3zve 3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects Against Picornaviruses.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H40 E71 G145 C147
Catalytic site (residue number reindexed from 1) H40 E71 G145 C147
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 G84 A F25 H40 N126 L127 G128 T142 R143 A144 C147 H161 V162 G163 G164 N165 H186 H188 F25 H40 N126 L127 G128 T142 R143 A144 C147 H161 V162 G163 G164 N165 H186 H188
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:3zve, PDBe:3zve, PDBj:3zve
PDBsum3zve
PubMed23388726
UniProtA1E4A3

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