Structure of PDB 3zv6 Chain A

Receptor sequence

>3zv6A (length=275) Species: 285 (Comamonas testosteroni)

MKLTGEVALITGGASGLGRALVDRFVAEGARVAVLDKSAERLRELEVAHG
GNAVGVVGDVRSLQDQKRAAERCLAAFGKIDTLIPNAGIWDYSTALADLP
EDKIDAAFDDIFHVNVKGYIHAVKACLPALVSSRGSVVFTISNAGFYPNG
GGPLYTATKHAVVGLVRQMAFELAPHVRVNGVAPGGMNTDLRGPSSLGLS
EQSISSVPLADMLKSVLPIGRMPALEEYTGAYVFFATRGDSLPATGALLN
YDGGMGVRGFLTAAGGADLPEKLNI

3D structure

• PDB: 3zv6 Biochemical Studies and Ligand-Bound Structures of Biphenyl Dehydrogenase from Pandoraea Pnomenusa Strain B-356 Reveal a Basis for Broad Specificity of the Enzyme.
• Chain: A
• Resolution: 2.14 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): G16 S142 Y155 K159
• Catalytic site (residue number reindexed from 1): G16 S142 Y155 K159
• Enzyme Commision number: 1.3.1.56: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G12 S15 G16 D36 K37 D59 V60 N86 G88 T140 S142 Y155 K159 M187 T189 D190 L191	G12 S15 G16 D36 K37 D59 V60 N86 G88 T140 S142 Y155 K159 M187 T189 D190 L191
BS02	4HB	A	W90 S142 N143 G150 Y155 L209	W90 S142 N143 G150 Y155 L209

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
• GO:0018509 cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity

Biological Process

• GO:0009056 catabolic process

External links

• PDB: RCSB:3zv6, PDBe:3zv6, PDBj:3zv6
• PDBsum: 3zv6
• PubMed: 21880718
• UniProt: Q46381|BPHB_COMTE Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (Gene Name=bphB)