Structure of PDB 3zu5 Chain A

Receptor sequence
>3zu5A (length=404) Species: 214092 (Yersinia pestis CO92) [Search protein sequence]
SHMLEMIIKPRVRGFICVTAHPTGCEANVKKQIDYVTTEGPIANGPKRVL
VIGASTGYGLAARITAAFGCGADTLGVFFERPGEEGKPGTSGWYNSAAFH
KFAAQKGLYAKSINGDAFSDEIKQLTIDAIKQDLGQVDQVIYSLASPRRT
HPKTGEVFNSALKPIGNAVNLRGLDTDKEVIKESVLQPATQSEIDSTVAV
MGGEDWQMWIDALLDAGVLAEGAQTTAFTYLGEKITHDIYWNGSIGAAKK
DLDQKVLAIRESLAAHGGGDARVSVLKAVVSQASSAIPMMPLYLSLLFKV
MKEKGTHEGCIEQVYSLYKDSLCGDSPHMDQEGRLRADYKELDPEVQNQV
QQLWDQVTNDNIYQLTDFVGYKSEFLNLFGFGIDGVDYDADVNPDVKIPN
LIQG
3D structure
PDB3zu5 Structure of the Yersinia Pestis Fabv Enoyl-Acp Reductase and its Interaction with Two 2-Pyridone Inhibitors
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI A G48 S50 T51 G52 Y53 F73 F74 E75 G110 D111 A112 S138 L139 A140 F223 T224 Y225 K244 A273 V274 G53 S55 T56 G57 Y58 F78 F79 E80 G115 D116 A117 S143 L144 A145 F228 T229 Y230 K249 A278 V279
BS02 AEW A Y225 Y235 A273 M285 Y230 Y240 A278 M290 MOAD: Ki=1.5uM
BindingDB: IC50=>1.00e+5nM
Gene Ontology
Molecular Function
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491 oxidoreductase activity
GO:0050343 trans-2-enoyl-CoA reductase (NADH) activity
GO:0051287 NAD binding
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3zu5, PDBe:3zu5, PDBj:3zu5
PDBsum3zu5
PubMed22244758
UniProtQ8Z9U1|FABV_YERPE Enoyl-[acyl-carrier-protein] reductase [NADH] (Gene Name=fabV)

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