Structure of PDB 3zu0 Chain A

Receptor sequence
>3zu0A (length=562) Species: 71421 (Haemophilus influenzae Rd KW20) [Search protein sequence]
HKAVELSILHINDHHSYLEPHETRINLNGQQTKVDIGGFSAVNAKLNKLR
KKYKNPLVLHAGDAITGTLYFTLFGGSADAAVMNAGNFHYFTLGNHEFDA
GNEGLLKLLEPLKIPVLSANVIPDKSSILYNKWKPYDIFTVDGEKIAIIG
LDTVNKTVNSSSPGKDVKFYDEIATAQIMANALKQQGINKIILLSHAGSE
KNIEIAQKVNDIDVIVTGDSHYLYGNDELRSLKLPVIYEYPLEFKNPNGE
PVFVMEGWAYSAVVGDLGVKFSPEGIASITRKIPHVLMSSHKLQVKNSEG
KWAELTGDERKKALDTLKSMKSISLDDHDAKTDKLIAKYKSEKDRLAQEI
VGVITGSAMPGGSANRIPNKAGSNPEGSIATRFIAETMYNELKTVDLTIQ
NAGGVRADILPGNVTFNDAYTFLPFGNTLYTYKMEGSLVKQVLEDAMQFA
LVDGSTGAFPYGAGIRYEANETPNAEGKRLVSVEVLNKTQQWEPIDDNKR
YLVGTNAYVAGGKDGYKTFGKLFNDPKYEGVDTYLPDAESFIKFMKKHPH
FEAYTSSNVKFN
3D structure
PDB3zu0 The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.
ChainA
Resolution2.001 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D44 H46 D94 N126 H127 D130 H227 D250 H252 G393 R397 R437
Catalytic site (residue number reindexed from 1) D13 H15 D63 N95 H96 D99 H196 D219 H221 G362 R366 R406
Enzyme Commision number 3.1.3.5: 5'-nucleotidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D94 N126 H227 D250 D63 N95 H196 D219
BS02 ZN A D44 H46 D94 H252 D13 H15 D63 H221
BS03 PO4 A H127 K187 D250 H252 H96 K156 D219 H221
BS04 A12 A H127 R397 N432 G435 R437 F456 N458 S486 G488 Y540 D546 H96 R366 N401 G404 R406 F425 N427 S455 G457 Y508 D514
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0008253 5'-nucleotidase activity
GO:0016787 hydrolase activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046872 metal ion binding
Biological Process
GO:0009166 nucleotide catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3zu0, PDBe:3zu0, PDBj:3zu0
PDBsum3zu0
PubMed21933152
UniProtP44569|5NTD_HAEIN NAD 5'-nucleotidase (Gene Name=HI_0206)

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