Structure of PDB 3ztv Chain A

Receptor sequence

>3ztvA (length=565) Species: 71421 (Haemophilus influenzae Rd KW20)

HKAVELSILHINDHHSYLEPHETRINLNGQQTKVDIGGFSAVNAKLNKLR
KKYKNPLVLHAGDAITGTLYFTLFGGSADAAVMNAGNFHYFTLGNHEFDA
GNEGLLKLLEPLKIPVLSANVIPDKSSILYNKWKPYDIFTVDGEKIAIIG
LDTVNKTVNSSSPGKDVKFYDEIATAQIMANALKQQGINKIILLSHAGSE
KNIEIAQKVNDIDVIVTGDSHYLYGNDELRSLKLPVIYEYPLEFKNPNGE
PVFVMEGWAYSAVVGDLGVKFSPEGIASITRKIPHVLMSSHKLQVKNSEG
KWAELTGDERKKALDTLKSMKSISLDDHDAKTDKLIAKYKSEKDRLAQEI
VGVITGSAMPGGSANRIPNKAGSNPEGSIATRFIAETMYNELKTVDLTIQ
NAGGVRADILPGNVTFNDAYTFLPFGNTLYTYKMEGSLVKQVLEDAMQFA
LVDGSTGAFPYGAGIRYEANETPNAEGKRLVSVEVLNKTQQWEPIDDNKR
YLVGTNAYVAGGKDGYKTFGKLFNDPKYEGVDTYLPDAESFIKFMKKHPH
FEAYTSSNVKFNAST

3D structure

• PDB: 3ztv The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism.
• Chain: A
• Resolution: 1.3 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D44 H46 D94 N126 H127 D130 H227 D250 H252 G393 R397 R437
• Catalytic site (residue number reindexed from 1): D13 H15 D63 N95 H96 D99 H196 D219 H221 G362 R366 R406
• Enzyme Commision number: 3.1.3.5: 5'-nucleotidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	D94 N126 H227 D250	D63 N95 H196 D219
BS02	ZN	A	D44 H46 D94 H252	D13 H15 D63 H221
BS03	ADN	A	N432 G434 G435 F456 N458 S486 G488 Y540 D546	N401 G403 G404 F425 N427 S455 G457 Y508 D514

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008253 5'-nucleotidase activity
• GO:0016787 hydrolase activity
• GO:0016788 hydrolase activity, acting on ester bonds
• GO:0046872 metal ion binding

Biological Process

• GO:0009166 nucleotide catabolic process

External links

• PDB: RCSB:3ztv, PDBe:3ztv, PDBj:3ztv
• PDBsum: 3ztv
• PubMed: 21933152
• UniProt: P44569|5NTD_HAEIN NAD 5'-nucleotidase (Gene Name=HI_0206)