Structure of PDB 3zt4 Chain A

Receptor sequence
>3zt4A (length=151) Species: 12721 (Human immunodeficiency virus) [Search protein sequence]
SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEDGIPYNPQSQGVIESMNK
ELKKIIGQVRDQAEHLKTAVQMAVFIHNHKRKGGYSAGERIVDIIATDIQ
T
3D structure
PDB3zt4 Small Molecule Inhibitors of the Ledgf Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZT2 A Q168 A169 E170 H171 T174 M178 Q112 A113 E114 H115 T118 M122 MOAD: Kd=1375uM
PDBbind-CN: -logKd/Ki=2.80,Kd=1570uM
BS02 ZT2 A Y83 H185 R187 S195 G197 E198 Y27 H129 R131 S136 G138 E139 MOAD: Kd=1375uM
PDBbind-CN: -logKd/Ki=2.80,Kd=1570uM
BS03 ZT2 A Q95 W132 Q39 W76 MOAD: Kd=1375uM
PDBbind-CN: -logKd/Ki=2.80,Kd=1570uM
BS04 ZT2 A R107 W108 P109 R51 W52 P53 MOAD: Kd=1375uM
PDBbind-CN: -logKd/Ki=2.80,Kd=1570uM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3zt4, PDBe:3zt4, PDBj:3zt4
PDBsum3zt4
PubMed22808106
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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