Structure of PDB 3zs4 Chain A

Receptor sequence

>3zs4A (length=244) Species: 83332 (Mycobacterium tuberculosis H37Rv)

MPLILLPAVDVVEGRAVRLVQGKAGSQTEYGSAVDAALGWQRDGAEWIHL
VDLDAAFGRGSNHELLAEVVGKLDVQVELSGGIRDDESLAAALATGCARV
NVGTAALENPQWCARVIGEHGDQVAVGLDVQIIDGEHRLRGRGWETDGGD
LWDVLERLDSEGCSRFVVTDITKDGTLGGPNLDLLAGVADRTDAPVIASG
GVSSLDDLRAIATLTHRGVEGAIVGKALYARRFTLPQALAAVRD

3D structure

• PDB: 3zs4 Crystal Structure of Mycobacterium Tuberculosis Phosphoribosyl Isomerase with Bound Prfar
• Chain: A
• Resolution: 1.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D11 D130
• Catalytic site (residue number reindexed from 1): D10 D129
• Enzyme Commision number: 5.3.1.16: 1-(5-phosphoribosyl)-5- [(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase.
  5.3.1.24: phosphoribosylanthranilate isomerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	1PR	A	A9 D11 R19 A57 F58 S81 G83 R85 G104 T105 D130 G144 W145 D175 G176 G201 G202 I224 G226 K227	A8 D10 R18 A56 F57 S80 G82 R84 G103 T104 D129 G143 W144 D174 G175 G200 G201 I223 G225 K226

Gene Ontology

Molecular Function

• GO:0003949 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
• GO:0004640 phosphoribosylanthranilate isomerase activity
• GO:0016853 isomerase activity

Biological Process

• GO:0000105 L-histidine biosynthetic process
• GO:0000162 tryptophan biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3zs4, PDBe:3zs4, PDBj:3zs4
• PDBsum: 3zs4
• UniProt: P9WMM5|HIS4_MYCTU Phosphoribosyl isomerase A (Gene Name=priA)