Structure of PDB 3zqz Chain A

Receptor sequence
>3zqzA (length=596) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
VKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAE
LAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLD
TLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWRE
FYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLE
DIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWS
EIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQD
FWDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHE
LGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLK
DYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCA
FWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFY
KSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDAL
EAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVS
3D structure
PDB3zqz Structural Characterization of Angiotensin I- Converting Enzyme in Complex with a Selenium Analogue of Captopril.
ChainA
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H337 A338 H367 E368 H371 E395 H497 Y507
Catalytic site (residue number reindexed from 1) H319 A320 H349 E350 H353 E377 H479 Y489
Enzyme Commision number 3.4.15.1: peptidyl-dipeptidase A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H367 H371 E395 H349 H353 E377
BS02 SLC A Q265 H337 A338 H367 E368 K495 H497 Y504 Y507 Q247 H319 A320 H349 E350 K477 H479 Y486 Y489
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zqz, PDBe:3zqz, PDBj:3zqz
PDBsum3zqz
PubMed21810173
UniProtQ10714|ACE_DROME Angiotensin-converting enzyme (Gene Name=Ance)

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