Structure of PDB 3zot Chain A

Receptor sequence
>3zotA (length=178) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence]
RAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTH
ALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQK
FSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGW
FDLFGMANGAHIAGLAVGLAMAFVDSLN
3D structure
PDB3zot Structure of Rhomboid Protease in Complex with Beta-Lactam Inhibitors Defines the S2' Cavity.
ChainA
Resolution2.399 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.105: rhomboid protease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L6C A M149 H150 F153 N154 W157 S201 V204 Y205 W236 H254 M58 H59 F62 N63 W66 S110 V113 Y114 W145 H161 PDBbind-CN: -logKd/Ki=5.95,IC50=1.117uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zot, PDBe:3zot, PDBj:3zot
PDBsum3zot
PubMed23665170
UniProtP09391|GLPG_ECOLI Rhomboid protease GlpG (Gene Name=glpG)

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