Structure of PDB 3zos Chain A

Receptor sequence
>3zosA (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
RVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLL
VAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMIT
DYMENGDLNQFLSAHQLEDAAQGPTISYPMLLHVAAQIASGMRYLATLNF
VHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAW
ECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFR
DQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNT
V
3D structure
PDB3zos Structural Mechanisms Determining Inhibition of the Collagen Receptor Ddr1 by Selective and Multi-Targeted Type II Kinase Inhibitors
ChainA
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D766 R770 N771 D784 A793
Catalytic site (residue number reindexed from 1) D154 R158 N159 D172 A181
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LI A A653 K655 E672 M676 T701 Y703 M704 V763 H764 R765 L773 I782 A783 D784 F785 A52 K54 E71 M75 T100 Y102 M103 V151 H152 R153 L161 I170 A171 D172 F173 PDBbind-CN: -logKd/Ki=8.89,Kd=1.3nM
BS02 0LI A V799 C814 I815 L816 G818 F861 V187 C202 I203 L204 G206 F249 PDBbind-CN: -logKd/Ki=8.89,Kd=1.3nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zos, PDBe:3zos, PDBj:3zos
PDBsum3zos
PubMed24768818
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1)

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