Structure of PDB 3zon Chain A

Receptor sequence
>3zonA (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
SQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVELRVVLKVLDPSHHDI
ALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRR
ERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGT
SPFIKLSDPGVGLGALSREERVERIPWLAPECLPLSTAMDKWGFGATLLE
ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPQLATLTSQCLTYEPTQRPSF
RTILRDLTRLQ
3D structure
PDB3zon Human Tyk2 Pseudokinase Domain Bound to a Kinase Inhibitor
ChainA
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N734 R738 N739 D759
Catalytic site (residue number reindexed from 1) N133 R137 N138 D158
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IK1 A V640 K642 T687 E688 Y689 V690 L741 V39 K41 T86 E87 Y88 V89 L140
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3zon, PDBe:3zon, PDBj:3zon
PDBsum3zon
PubMed
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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