Structure of PDB 3zns Chain A

Receptor sequence
>3znsA (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]
LPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCE
CLRGRKASLEELQSVHSERHVLLYGTNPLSVMLPCGGVGVDTDTIWNELH
SSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFN
SVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHD
DGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVM
PIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG
AVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRS
LEAVIRVHSKYWGCMQRL
3D structure
PDB3zns Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D707 H709 D801 D174 H176 D268
BS02 ZN A C533 C535 H541 C618 C18 C20 H26 C85
BS03 NU7 A P542 P667 H669 H670 G678 F679 D707 H709 F738 L810 G841 P27 P134 H136 H137 G145 F146 D174 H176 F205 L277 G308 MOAD: Ki=0.039uM
PDBbind-CN: -logKd/Ki=7.41,Ki=39nM
BindingDB: Ki=39nM
External links
PDB RCSB:3zns, PDBe:3zns, PDBj:3zns
PDBsum3zns
PubMed23524983
UniProtQ8WUI4|HDAC7_HUMAN Histone deacetylase 7 (Gene Name=HDAC7)

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