Structure of PDB 3znr Chain A

Receptor sequence
>3znrA (length=368) Species: 9606 (Homo sapiens) [Search protein sequence]
LPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCE
CLRGRKASLEELQSVHSERHVLLYGTNPLSVMLPCGGVGVDTDTIWNELH
SSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFN
SVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHD
DGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVM
PIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGG
AVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRS
LEAVIRVHSKYWGCMQRL
3D structure
PDB3znr Selective Class Iia Histone Deacetylase Inhibition Via a Non-Chelating Zinc Binding Group
ChainA
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D707 H709 D801 D174 H176 D268
BS02 ZN A C533 C535 H541 C618 C18 C20 H26 C85
BS03 NU9 A P542 E543 P667 H669 H670 G678 F679 D707 H709 F738 L810 E840 G841 H843 P27 E28 P134 H136 H137 G145 F146 D174 H176 F205 L277 E307 G308 H310 MOAD: Ki=0.036uM
PDBbind-CN: -logKd/Ki=7.44,Ki=36nM
BindingDB: Ki=46nM,IC50=4.1nM
External links
PDB RCSB:3znr, PDBe:3znr, PDBj:3znr
PDBsum3znr
PubMed23524983
UniProtQ8WUI4|HDAC7_HUMAN Histone deacetylase 7 (Gene Name=HDAC7)

[Back to BioLiP]