Structure of PDB 3zmm Chain A

Receptor sequence
>3zmmA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
FEERHLKFLQQLGGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFER
EIEILKSLQHDNIVKYKGVCYRNLKLIMEYLPYGSLRDYLQAHAERIDHI
KLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVL
PQDKEYYKVESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSK
SPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTEC
WNNNVNQRPSFRDLALRVDQIRDQM
3D structure
PDB3zmm Discovery of Novel Jak2-Stat Pathway Inhibitors with Extended Residence Time on Target.
ChainA
Resolution2.51 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D976 A978 R980 N981 D994 S1016
Catalytic site (residue number reindexed from 1) D125 A127 R129 N130 D143 S161
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F9J A L855 A880 M929 E930 Y931 L932 G935 N981 L983 G993 L12 A33 M78 E79 Y80 L81 G84 N130 L132 G142 PDBbind-CN: -logKd/Ki=9.14,Ki=0.72nM
BindingDB: Ki=0.720000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3zmm, PDBe:3zmm, PDBj:3zmm
PDBsum3zmm
PubMed23562594
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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