Structure of PDB 3zmh Chain A

Receptor sequence
>3zmhA (length=180) Species: 562 (Escherichia coli) [Search protein sequence]
ERAGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFT
HALMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQ
KFSGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAG
WFDLFGMSMANGAHIAGLAVGLAMAFVDSL
3D structure
PDB3zmh Structure of rhomboid protease in complex with beta-lactam inhibitors defines the S2' cavity.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.105: rhomboid protease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L62 A M149 H150 F153 N154 W157 S201 V204 Y205 M208 W236 M247 H254 M59 H60 F63 N64 W67 S111 V114 Y115 M118 W146 M157 H164 PDBbind-CN: -logKd/Ki=5.28,IC50=5.267uM
BS02 78C A F153 W157 F232 W236 F63 W67 F142 W146
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zmh, PDBe:3zmh, PDBj:3zmh
PDBsum3zmh
PubMed23665170
UniProtP09391|GLPG_ECOLI Rhomboid protease GlpG (Gene Name=glpG)

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