Structure of PDB 3zlo Chain A

Receptor sequence
>3zloA (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
SQSNRELVVDFLSYKLSQKGYSWSQTESEAVKQALREAGDEFELRYRRAF
SDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESV
DKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
3D structure
PDB3zlo Structure-Guided Design of a Selective Bcl-Xl Inhibitor
ChainA
Resolution2.601 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 X8U A A93 F97 Y101 F105 S106 L108 T109 L130 N136 G138 R139 A142 S145 F146 Y195 G196 A38 F42 Y46 F50 S51 L53 T54 L75 N81 G83 R84 A87 S90 F91 Y140 G141 PDBbind-CN: -logKd/Ki=8.82,IC50=1.5nM
BindingDB: IC50=1.5nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3zlo, PDBe:3zlo, PDBj:3zlo
PDBsum3zlo
PubMed23603658
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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