Structure of PDB 3zln Chain A

Receptor sequence
>3zlnA (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
MSQSNRELVVDFLSYKLSQKGYSWSQFTESEAVKQALREAGDEFELRYRR
AFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVE
SVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
3D structure
PDB3zln Structure-Guided Design of a Selective Bcl-Xl Inhibitor
ChainA
Resolution2.288 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H0Y A F97 F105 S106 D107 L108 T109 E129 L130 R132 N136 G138 R139 S145 F146 G196 F44 F52 S53 D54 L55 T56 E76 L77 R79 N83 G85 R86 S92 F93 G143 MOAD: Kd=3.4nM
PDBbind-CN: -logKd/Ki=8.47,Kd=3.4nM
BindingDB: IC50=20nM,Kd=4.1nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3zln, PDBe:3zln, PDBj:3zln
PDBsum3zln
PubMed23603658
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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