Structure of PDB 3zks Chain A

Receptor sequence
>3zksA (length=360) Species: 9606 (Homo sapiens) [Search protein sequence]
ANFLAMVDNLQGGYYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDT
YFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIA
TIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVF
SMQMCGGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLN
LDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTG
SQLACWTPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMYECYRFGIS
PSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFS
TEDVASNCVP
3D structure
PDB3zks Mapping the Conformational Space Accessible to Bace2 Using Surface Mutants and Co-Crystals with Fab-Fragments, Fynomers, and Xaperones
ChainA
Resolution2.11 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D48 S51 N53 A55 Y87 D241 T244
Catalytic site (residue number reindexed from 1) D32 S35 N37 A39 Y71 D214 T217
Enzyme Commision number 3.4.23.45: memapsin 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WZV A G29 L46 D48 Y87 I134 D241 G243 T245 A347 G13 L30 D32 Y71 I118 D214 G216 T218 A310
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zks, PDBe:3zks, PDBj:3zks
PDBsum3zks
PubMed23695257
UniProtQ9Y5Z0|BACE2_HUMAN Beta-secretase 2 (Gene Name=BACE2)

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