Structure of PDB 3zir Chain A

Receptor sequence

>3zirA (length=426) Species: 10090 (Mus musculus) [Search protein sequence]

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS

3D structure

PDB

3zir Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-Alpha

Chain

Resolution

2.3 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	T151 A163 N361 R366 Q367
Catalytic site (residue number reindexed from 1)	T80 A92 N290 R295 Q296
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	G281 R315 V321 T322 K353 E354 W357 N361 E396 W399 T402 N403 S406 D442	G210 R244 V250 T251 K282 E283 W286 N290 E325 W328 T331 N332 S335 D371
BS02	peptide	A	L104 S105 F138 W142 N146 S149 T155 Q181 W184 N188 D192 W231 R238	L33 S34 F67 W71 N75 S78 T84 Q110 W113 N117 D121 W160 R167

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:3zir, PDBe:3zir, PDBj:3zir
PDBsum	3zir
PubMed	23910026
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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