Structure of PDB 3ziq Chain A

Receptor sequence
>3ziqA (length=426) Species: 10090 (Mus musculus) [Search protein sequence]
GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYFS
3D structure
PDB3ziq Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-Alpha
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T151 A163 N361 R366 Q367
Catalytic site (residue number reindexed from 1) T80 A92 N290 R295 Q296
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W142 N146 S149 G150 T155 Q181 W184 N188 D192 W231 R238 W71 N75 S78 G79 T84 Q110 W113 N117 D121 W160 R167
BS02 peptide A G281 R315 V321 T322 K353 W357 N361 E396 W399 T402 N403 S406 G210 R244 V250 T251 K282 W286 N290 E325 W328 T331 N332 S335
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ziq, PDBe:3ziq, PDBj:3ziq
PDBsum3ziq
PubMed23910026
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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