Structure of PDB 3zi0 Chain A

Receptor sequence
>3zi0A (length=357) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
RLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQT
GVTNIAVIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAALKTGAR
LALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPDEVAKL
VLTASGGPFRGWSAADLEHVTPEQAGPMNTLNSASLVNKGLEVIETHLLF
GIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLALGWPRR
VSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTAVYNAAN
EEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDAQRWARE
RAQRAVS
3D structure
PDB3zi0 Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FM8 A S152 E153 A176 S177 N209 S213 N218 K219 S245 P265 S130 E131 A154 S155 N179 S183 N188 K189 S215 P235 MOAD: Kd=0.04uM
PDBbind-CN: -logKd/Ki=7.40,Kd=0.04uM
BindingDB: IC50=13000nM,Kd=40nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016491 oxidoreductase activity
GO:0030145 manganese ion binding
GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO:0046872 metal ion binding
GO:0050897 cobalt ion binding
GO:0070402 NADPH binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
GO:0051483 terpenoid biosynthetic process, mevalonate-independent
GO:0051484 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3zi0, PDBe:3zi0, PDBj:3zi0
PDBsum3zi0
PubMed23819803
UniProtP9WNS1|DXR_MYCTU 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Gene Name=dxr)

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