Structure of PDB 3zhz Chain A

Receptor sequence
>3zhzA (length=365) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQ
TGVTNIAVADEDIPYHGSDAATRLVEQTEADVVLNALVGALGLRPTLAAL
KTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQCLRGGTPD
EVAKLVLTASGGPFRGWSAADLEHVTPEQAGAHPNTLNSASLVNKGLEVI
ETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDMKLPISLA
LGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGVAGGCMTA
VYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPATVDDVLDA
QRWARERAQRAVSGM
3D structure
PDB3zhz Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
ChainA
Resolution2.25 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FM7 A S152 E153 A176 S177 S213 N218 K219 M267 S135 E136 A159 S160 S189 N194 K195 M243 MOAD: Kd=0.09uM
PDBbind-CN: -logKd/Ki=7.05,Kd=0.09uM
BindingDB: Kd=90nM,IC50=19000nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016491 oxidoreductase activity
GO:0030145 manganese ion binding
GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO:0046872 metal ion binding
GO:0050897 cobalt ion binding
GO:0070402 NADPH binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
GO:0051483 terpenoid biosynthetic process, mevalonate-independent
GO:0051484 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3zhz, PDBe:3zhz, PDBj:3zhz
PDBsum3zhz
PubMed23819803
UniProtP9WNS1|DXR_MYCTU 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Gene Name=dxr)

[Back to BioLiP]