Structure of PDB 3zhx Chain A

Receptor sequence
>3zhxA (length=372) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
GRLRVVVLGSTGSIGTQALQVIADNPDRFEVVGLAAGGAHLDTLLRQRAQ
TGVTNIAVADEHAAQRVGDIPYHGSDAATRLVEQTEADVVLNALVGALGL
RPTLAALKTGARLALANKESLVAGGSLVLRAARPGQIVPVDSEHSALAQC
LRGGTPDEVAKLVLTASGGPFRGWSAADLEHVTPEQAGAPMNTLNSASLV
NKGLEVIETHLLFGIPYDRIDVVVHPQSIIHSMVTFIDGSTIAQASPPDM
KLPISLALGWPRRVSGAAAACDFHTASSWEFEPLDTDVFPAVELARQAGV
AGGCMTAVYNAANEEAAAAFLAGRIGFPAIVGIIADVLHAADQWAVEPAT
VDDVLDAQRWARERAQRAVSGM
3D structure
PDB3zhx Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.267: 1-deoxy-D-xylulose-5-phosphate reductoisomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D151 E153 E222 D141 E143 E205
BS02 FM6 A D151 S152 A176 S177 S213 N218 K219 S245 P265 M267 D141 S142 A166 S167 S196 N201 K202 S228 P248 M250 PDBbind-CN: -logKd/Ki=6.68,Kd=0.21uM
BindingDB: Kd=210nM,IC50=320nM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0016491 oxidoreductase activity
GO:0030145 manganese ion binding
GO:0030604 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO:0046872 metal ion binding
GO:0050897 cobalt ion binding
GO:0070402 NADPH binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
GO:0051483 terpenoid biosynthetic process, mevalonate-independent
GO:0051484 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3zhx, PDBe:3zhx, PDBj:3zhx
PDBsum3zhx
PubMed23819803
UniProtP9WNS1|DXR_MYCTU 1-deoxy-D-xylulose 5-phosphate reductoisomerase (Gene Name=dxr)

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