Structure of PDB 3zhv Chain A

Receptor sequence
>3zhvA (length=820) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
DKNARVIELIAAYRNRGHLMADIDPLRLDNTRFRSHPDLTLWDLDREFKQ
RKKLRDILSVLRDAYCRHVGVEYTHILEPEQQRWIQERVETKHDKPTVAE
QKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAETVIPMMDAVIDQCAEH
GLDEVVIAMPHRGRLNVLANIVGKPYSQIFSEFGDVKYHLGATGTYIQMF
GDNDIEVSLTANPSHLEAVDPVLEGLVRAKQDLLDTGEEGSDNRFSVVPL
MLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHIVVNNQIGFTTAPTDSR
SSEYCTDVAKMIGAPIFHVNGDDPEACAWVARLAVDFRQAFKKDVVIDML
CYRRRGHNEGDDPSMTQPYMYDVIDTKRGSRKAYTEALIGRGDISMKEAE
DALRDYQGQLERVFNEVRELEKHLATAVDKAMLQRIGDAHLALPEGFTVH
PRVRPVLEKRREMAYEGRIDWAFAELLALGSLIAEGKLVRLSGQDTQRGT
FTQRHAVIVDRKTGEEFTPLQLLATNPDGTPTGGKFLVYNSALSEFAAVG
FEYGYSVGNPDAMVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSDVVL
LLPHGHEGQGPDHTSGRIERFLQLWAEGSMTIAMPSTPANYFHLLRRHGK
DGIQRPLIVFTPKSMLRNKAAVSDIRDFTESKFRSVLEEPMYTDGEGDRN
KVTRLLLTSGKIYYELAARKAKENREDVAIVRIEQLAPLPRRRLAETLDR
YPNVKEKFWVQEEPANQGAWPSFGLTLPEILPDHFTGLKRISRRAMSAPS
SGSSKVHAVEQQEILDTAFG
3D structure
PDB3zhv A Dual Conformation of the Post-Decarboxylation Intermediate is Associated with Distinct Enzyme States in Mycobacterial Alpha-Ketoglutarate Decarboxylase (Kgd).
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.2.4.2: oxoglutarate dehydrogenase (succinyl-transferring).
2.2.1.5: 2-hydroxy-3-oxoadipate synthase.
2.3.1.61: dihydrolipoyllysine-residue succinyltransferase.
4.1.1.71: 2-oxoglutarate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TDW A R540 S604 L606 G644 D645 A646 A647 Q651 N678 I680 H747 R162 S214 L216 G254 D255 A256 A257 Q261 N288 I290 H357
BS02 MG A D645 N678 I680 D255 N288 I290
BS03 CA A D1004 H1055 D1058 I1060 D597 H648 D651 I653
BS04 TDW A Q901 L950 E952 Q976 F980 Q494 L543 E545 Q569 F573
Gene Ontology
Molecular Function
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0030976 thiamine pyrophosphate binding

View graph for
Molecular Function
External links
PDB RCSB:3zhv, PDBe:3zhv, PDBj:3zhv
PDBsum3zhv
PubMed24171907
UniProtA0R2B1|KGD_MYCS2 Multifunctional 2-oxoglutarate metabolism enzyme (Gene Name=kgd)

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