Structure of PDB 3zh2 Chain A

Receptor sequence
>3zh2A (length=314) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
PKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTN
VMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLN
NKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGG
VLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQE
FINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLK
DLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKF
DEAIAETKRMKALA
3D structure
PDB3zh2 Structural Basis for Discriminatory Recognition of Plasmodium Lactate Dehydrogenase by a DNA Aptamer
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R95 D155 R158 H182
Catalytic site (residue number reindexed from 1) R93 D153 R156 H180
Enzyme Commision number 1.1.1.27: L-lactate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A D35 I36 A80 F82 K84 A85 P86 G87 K88 S89 D90 V229 H232 A233 S234 D33 I34 A78 F80 K82 A83 P84 G85 K86 S87 D88 V227 H230 A231 S232 PDBbind-CN: Kd=42nM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004459 L-lactate dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060 L-malate dehydrogenase (NAD+) activity
Biological Process
GO:0006096 glycolytic process
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:3zh2, PDBe:3zh2, PDBj:3zh2
PDBsum3zh2
PubMed24043813
UniProtQ76NM3

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