Structure of PDB 3zg0 Chain A

Receptor sequence

>3zg0A (length=642) Species: 158878 (Staphylococcus aureus subsp. aureus Mu50)

DKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEVEMTERPIKIYNSLGVK
DINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKEDGMWKLD
WDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPK
NVSKKDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSD
FAKKFHLTTNETESRNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDA
VIGKKGLEKLYDKKLQHEDGYRVTIVDDNSNTIAHTLIEKKKKDGKDIQL
TIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMS
NEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLDDKTSYK
IDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGS
KKFEKGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILI
NPVQILSIYSALENNGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQ
QVVNKTHKEDIYRSYANLIGKSGTAELKMKQGETGRQIGWFISYDKDNPN
MMMAINVKDVQDKGMASYNAKISGKVYDELYENGNKKYDIDE

3D structure

• PDB: 3zg0 How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function
• Chain: A
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AI8	A	S403 Y446 E447 S461 S462 N464 Y519 Q521 T582 S598 T600 A601 E602	S377 Y420 E421 S435 S436 N438 Y493 Q495 T556 S572 T574 A575 E576
BS02	1W8	A	Y105 I144 E145 N146	Y79 I118 E119 N120
BS03	MUR	A	E150 R151 T165 S240 R241 V277 H293	E124 R125 T139 S214 R215 V251 H267
BS04	1W8	A	N307 I309	N281 I283

Gene Ontology

Molecular Function

• GO:0008658 penicillin binding
• GO:0071972 peptidoglycan L,D-transpeptidase activity

Biological Process

• GO:0046677 response to antibiotic
• GO:0071555 cell wall organization

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3zg0, PDBe:3zg0, PDBj:3zg0
• PDBsum: 3zg0
• PubMed: 24085846
• UniProt: A0A0H3JPA5