Structure of PDB 3zfz Chain A

Receptor sequence

>3zfzA (length=635) Species: 158878 (Staphylococcus aureus subsp. aureus Mu50)

DKEINNTIDAIEDKNFKQVYKDSSYISKSDNGEVEMTERPIKIYNSLGVK
DINIQDRKIKKVSKNKKRVDAQYKIKTNYGNIDRNVQFNFVKEDGMWKLD
WDHSVIIPGMQKDQSIHIENLKSERGKILDRNNVELANTGTAYEIGIVPK
NVSKKDYKAIAKELSISEDYIKQQMDQNWVQDDTFVPLKTVKKMDEYLSD
FAKKFHLTTNETESRNYPLGKATSHLLGYVGPINSEELKQKEYKGYKDDA
VIGKKGLEKLYDKKLQHEDGYRVTIVDDNSNTIAHTLIEKKKKDGKDIQL
TIDAKVQKSIYNNMKNDYGSGTAIHPQTGELLALVSTPSYDVYPFMYGMS
NEEYNKLTEDKKEPLLNKFQITTSPGSTQKILTAMIGLNNKTLDDKTSYK
IDGKGWQKDKSWGGYNVTRYEVVNGNIDLKQAIESSDNIFFARVALELGS
KKFEKGMKKLGVGEDIPSDYPFYNAQISNKNLDNEILLADSGYGQGEILI
NPVQILSIYSALENNGNINAPHLLKDTKNKVWKKNIISKENINLLTDGMQ
QVVNKTHKEDIYRSYANLIGKSGTAELGRQIGWFISYDKDNPNMMMAINV
KDVQDKGMASYNAKISGKVYDELYENGNKKYDIDE

3D structure

• PDB: 3zfz How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2A Enables Methicillin Resistance and Physiological Function
• Chain: A
• Resolution: 2.25 Å

Enzymatic activity

• Enzyme Commision number: 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	AI8	A	S403 K406 Y446 S461 S462 N464 Y519 G520 Q521 T582 S598 T600 A601 E602	S377 K380 Y420 S435 S436 N438 Y493 G494 Q495 T556 S572 T574 A575 E576
BS02	1W8	A	N104 Y105 I144 E145 N146	N78 Y79 I118 E119 N120
BS03	MUR	A	E150 R151 E239 S240 R241 V256 V277 M372	E124 R125 E213 S214 R215 V230 V251 M346

Gene Ontology

Molecular Function

• GO:0008658 penicillin binding
• GO:0071972 peptidoglycan L,D-transpeptidase activity

Biological Process

• GO:0046677 response to antibiotic
• GO:0071555 cell wall organization

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3zfz, PDBe:3zfz, PDBj:3zfz
• PDBsum: 3zfz
• PubMed: 24085846
• UniProt: A0A0H3JPA5