Structure of PDB 3zdz Chain A

Receptor sequence

>3zdzA (length=455) Species: 9606 (Homo sapiens)

LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEET
GGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSW
SDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNT
LSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPV
ADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNT
TEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNG
DGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGT
QLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLR
SRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRA
QPVVK

3D structure

• PDB: 3zdz Complete Integrin Headpiece Opening in Eight Steps.
• Chain: A
• Resolution: 2.75 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y189 Y190 L192 D224 S225 F231	Y189 Y190 L192 D224 S225 F231
BS02	CA	A	E243 D245 D247 T250 E252	E243 D245 D247 T250 E252
BS03	CA	A	D297 N299 D301 R303 D305	D297 N299 D301 R303 D305
BS04	CA	A	D365 D367 D369 Y371 D373	D365 D367 D369 Y371 D373
BS05	CA	A	D426 D428 N430 Y432 D434	D426 D428 N430 Y432 D434

Gene Ontology

Biological Process

• GO:0007155 cell adhesion

Cellular Component

• GO:0008305 integrin complex

External links

• PDB: RCSB:3zdz, PDBe:3zdz, PDBj:3zdz
• PDBsum: 3zdz
• PubMed: 23798730
• UniProt: P08514|ITA2B_HUMAN Integrin alpha-IIb (Gene Name=ITGA2B)