Structure of PDB 3zds Chain A

Receptor sequence
>3zdsA (length=425) Species: 160488 (Pseudomonas putida KT2440) [Search protein sequence]
LHYLSGFGNEFASEALPGALPVGQNSPQKAPYGLYAELLSGTAFTMARSE
LRRTWLYRIRPSALHPRFERLARQPLGGPLGGINPNRLRWSPQPIPAEPT
DFIEGWLPMAANAGAEKPAGVSIYIYRANRSMERVFFNADGELLLVPEQG
RLRIATELGVMEVEPLEIAVIPRGMKFRVELLDGQARGYIAENHGAPLRL
PDLGPIGSNGLANPRDFLTPVAHYEEAEGPVQLVQKFLGEHWACELQHSP
LDVVAWHGSNVPYKYDLRRFNTIGTVSFDHPDPSIFTVLTSPTSVHGMAN
MDFVIFPPRWMVAENTFRPPWFHRNLMNEFMGLINGAYDAKAEGFLPGGA
SLHGVMSAHGPDAETCEKAIAADLAPHKIDNTMAFMFETSQVLRPSLQAL
ECPQLQADYDSCWATLPSTFNPNRR
3D structure
PDB3zds Visualizing the Substrate-, Superoxo-, Alkylperoxo- and Product-Bound States at the Non-Heme Fe(II) Site of Homogentisate Dioxygenase
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H288 H331 E337 H361 H367
Catalytic site (residue number reindexed from 1) H280 H323 E329 H353 H359
Enzyme Commision number 1.13.11.5: homogentisate 1,2-dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H331 E337 H367 H323 E329 H359
BS02 M8O A H288 P291 P328 W329 H331 M339 Y346 H367 M394 H280 P283 P320 W321 H323 M331 Y338 H359 M386
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0001217 DNA-binding transcription repressor activity
GO:0004411 homogentisate 1,2-dioxygenase activity
GO:0005506 iron ion binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006559 L-phenylalanine catabolic process
GO:0006570 tyrosine metabolic process
GO:0006572 tyrosine catabolic process
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005737 cytoplasm
GO:0032993 protein-DNA complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zds, PDBe:3zds, PDBj:3zds
PDBsum3zds
PubMed23858455
UniProtQ88E47|HGD_PSEPK Homogentisate 1,2-dioxygenase (Gene Name=hmgA)

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