Structure of PDB 3zd7 Chain A

Receptor sequence

>3zd7A (length=623) Species: 9606 (Homo sapiens)

NLYSPFKPRNYQLELALPAMKGKNTIICAPTGCGKTFVSLLICEHHLKKF
PQGQKGKVVFFANQIPVYEQNKSVFSKYFERHGYRVTGISGATAVPVEQI
VENNDIIILTPQILVNNLKKGTIPSLSIFTLMIFDECHNTSKQHPYNMIM
FNYLDQKLGGSSGPLPQVIGLTASVGVGDAKNTDEALDYICKLCASLDAS
VIATVKHNLEELEQVVYKPQKFFRKVESRISDKFKYIIAQLMRDTESLAK
RICKDLENLSQSQNREFGTQKYEQWIVTVQKACMSRICKALFLYTSHLRK
YNDALIISEHARMKDALDYLKDFFSNVRAAGFDEIEQDLTQRFEEKLQEL
ESVSRDPSNENPKLEDLCFILQEEYHLNPETITILFVKTRALVDALKNWI
EGNPKLSFLKPGILTNILILTSVADEGIDIAQCNLVILYEYVGNARGSKC
FLLTSNAGVIEKEQINMYKEKMMNDSILRLQTWDEAVFREKILHIQTHEK
FIRDSKENKKLLCRKCKALACYTADVRVIEDCHYTVLGDAFKECFVSRPH
PKPKQFSSFEKRAKIFCARQNCSHDWGIHVKYKTFEIPVIKIESFVVEDT
GVQTLYSKWKDFHFEKIPFDPAE

3D structure

• PDB: 3zd7 Defining the Functional Determinants for RNA Surveillance by Rig-I.
• Chain: A
• Resolution: 2.5 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K379 Q380 H381 K508 C829 H830 F853 V886 K888	K142 Q143 H144 K271 C532 H533 F556 V589 K591
BS02	rna	A	Q299 I300 S325 G326 T347 Q349 N353 F853	Q64 I65 S90 G91 T110 Q112 N116 F556
BS03	ZN	A	C810 C864 C869	C513 C567 C572
BS04	ADP	A	L237 K242 R244 Q247 T266 G267 C268 G269 K270 T271 F272	L2 K7 R9 Q12 T31 G32 C33 G34 K35 T36 F37

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:3zd7, PDBe:3zd7, PDBj:3zd7
• PDBsum: 3zd7
• PubMed: 23897087
• UniProt: O95786|RIGI_HUMAN Antiviral innate immune response receptor RIG-I (Gene Name=RIGI)