Structure of PDB 3zcw Chain A

Receptor sequence
>3zcwA (length=321) Species: 9606 (Homo sapiens) [Search protein sequence]
NIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGDKSSRKTYTFD
MVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGER
SPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELF
DLLNLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATL
MNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDLAGSENNINQSL
LTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLN
LEETLSTLEYAHRAKNILNKP
3D structure
PDB3zcw Structural Insights Into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein.
ChainA
Resolution1.691 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R26 P27 T107 G108 G110 K111 T112 F113 R9 P10 T88 G89 G91 K92 T93 F94
BS02 4A2 A Y104 S269 N289 L292 L293 L295 G296 R297 I299 T300 Y352 Y85 S242 N247 L250 L251 L253 G254 R255 I257 T258 Y310 MOAD: Kd=0.65uM
PDBbind-CN: -logKd/Ki=6.19,Kd=0.65uM
BS03 4A2 A E116 I136 L160 L172 I213 K216 G217 A218 K220 R221 M228 E97 I117 L141 L153 I186 K189 G190 A191 K193 R194 M201 MOAD: Kd=0.65uM
PDBbind-CN: -logKd/Ki=6.19,Kd=0.65uM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3zcw, PDBe:3zcw, PDBj:3zcw
PDBsum3zcw
PubMed23305346
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

[Back to BioLiP]