Structure of PDB 3zbf Chain A

Receptor sequence
>3zbfA (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
IENLPAFPREKLTLRLLLGSGEVYEGTAVDILGVGSGEIKVAVKTLKKGS
TDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLT
YLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCL
VSVKDYTSPRIVKIGDFGLARDIYLPVRWMAPESLMDGIFTTQSDVWSFG
ILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCW
AQEPDQRPTFHRIQDQLQLFRNFFLNSIYKS
3D structure
PDB3zbf Acquired Resistance to Crizotinib from a Mutation in Cd74-Ros1
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D2079 A2081 R2083 N2084 D2102
Catalytic site (residue number reindexed from 1) D143 A145 R147 N148 D166
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VGH A L1951 A1978 M2029 G2032 D2033 N2084 L2086 G2101 D2102 S2229 L18 A42 M93 G96 D97 N148 L150 G165 D166 S281 MOAD: Ki=2.1nM
PDBbind-CN: -logKd/Ki=7.52,IC50=30nM
BindingDB: IC50=6.5nM,Kd=4.1nM,Ki=0.600000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3zbf, PDBe:3zbf, PDBj:3zbf
PDBsum3zbf
PubMed23724914
UniProtP08922|ROS1_HUMAN Proto-oncogene tyrosine-protein kinase ROS (Gene Name=ROS1)

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