Structure of PDB 3x43 Chain A

Receptor sequence
>3x43A (length=316) Species: 1914 (Streptomyces lavendulae) [Search protein sequence]
PLFNSILDTIGRTPIVRLQRMAPEHTSVYVKVESFNPGGSVKDRLALSVV
LDAEAKGLLKPGDTIVECTSGNVGIALAMVAAARGYRFVAVMGDTYSVER
RKLIRAYGGKLVLFPGHLGSKGGNLIADELAEKYGWFRARQFDNPANPSY
HRETTASEILADFAGKRLDHFVTGFGTTGTLTGVGQMLRVARPEVRVVAL
EPSNAAMLARGEWSPHQIQGLAPNFVPGVLDRSVIDDLVTMDEVTARDTS
RRLAAEEGIFAGISAGATVATALSIAEHAPEGTVLLAMLPDTGERYLSTF
LFDGVDEGSDDAWLAS
3D structure
PDB3x43 The structural and mutational analyses of O-ureido-L-serine synthase necessary for D-cycloserine biosynthesis.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K43 S265
Catalytic site (residue number reindexed from 1) K42 S264
Enzyme Commision number 2.5.1.47: cysteine synthase.
2.6.99.3: O-ureido-L-serine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A K43 N73 F176 G177 T178 T179 T181 G221 S265 P291 D292 K42 N72 F175 G176 T177 T178 T180 G220 S264 P290 D291
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0017000 antibiotic biosynthetic process
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3x43, PDBe:3x43, PDBj:3x43
PDBsum3x43
PubMed26207937
UniProtD2Z027|DCSD_STRLA O-ureido-L-serine synthase (Gene Name=dcsD)

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