Structure of PDB 3x2f Chain A

Receptor sequence
>3x2fA (length=406) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence]
NTGEMKINWVSRYMPLLNKIAEEYSREKPLSGFTVGMSIHLEAKTAYLAI
TLSKLGAKVVITGSNPLSTQDDVAEALRSKGITVYARRTHDESIYRENLM
KVLDERPDFIIDDGGDLTVISHTEREEVLENLKGVSEETTTGVRRLKALE
ETGKLRVPVIAVNDSKMKYLFDNRYGTGQSTWDAIMRNTNLLVAGKNVVV
AGYGWCGRGIALRAAGLGARVIVTEVDPVKAVEAIMDGFTVMPMKEAVKI
ADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEIAVEK
FEARPNVTGYTLENGKTVFLLAEGRLVNLAAGDGHPVEIMDLSFALQIFA
VLYLLENHRKMSPKVYMLPDEIDERVARMKLDSLGVKIDELTEKQRRYLR
SWQHHH
3D structure
PDB3x2f Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacterium Thermotoga maritima.
ChainA
Resolution2.04 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H42 G65 S70 D115 E140 N165 K170 D174 N175 T179 H285 H337 S345 Q349
Catalytic site (residue number reindexed from 1) H40 G63 S68 D113 E138 N163 K168 D172 N173 T177 H283 H335 S343 Q347
Enzyme Commision number 3.13.2.1: adenosylhomocysteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI A T142 T143 D174 T179 G204 G206 W207 C208 T226 E227 V228 S260 G261 N262 A283 H285 N330 H337 T140 T141 D172 T177 G202 G204 W205 C206 T224 E225 V226 S258 G259 N260 A281 H283 N328 H335
Gene Ontology
Molecular Function
GO:0004013 adenosylhomocysteinase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0033353 S-adenosylmethionine cycle
GO:0071269 L-homocysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3x2f, PDBe:3x2f, PDBj:3x2f
PDBsum3x2f
PubMed25791616
UniProtO51933|SAHH_THEMA Adenosylhomocysteinase (Gene Name=ahcY)

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