Structure of PDB 3x0v Chain A

Receptor sequence

>3x0vA (length=509) Species: 5547 (Trichoderma viride)

ELPPRKVCIVGAGVSGLYIAMILDDLKIPNLTYDIFESSSRTGGRLYTHH
FTDAKHDYYDIGAMRYPDIPSMKRTFNLFKRTGMPLIKYYLDGENTPQLY
NNHFFAKGVVDPYMVSVANGGTVPDDVVDSVGEKLQQAFGYYKEKLAEDF
DKGFDELMLVDDMTTREYLKRGGPKGEAPKYDFFAIQWMETQNTGTNLFD
QAFSESVIDSFDFDNPTKPEWYCIEGGTSLLVDAMKETLVHKVQNNKRVE
AISIDLDAPDDGNMSVKIGGKDYSGYSTVFNTTALGCLDRMDLRGLNLHP
TQADAIRCLHYDNSTKVALKFSYPWWIKDCGITCGGAASTDLPLRTCVYP
SYNLGDTGEAVLLASYTWSQDATRIGSLVKDAPPQPPKEDELVELILQNL
ARLHAEHMTYEKIKEAYTGVYHAYCWANDPNVGGAFALFGPGQFSNLYPY
LMRPAAGGKFHIVGEASSVHHAWIIGSLESAYTAVYQFLYKYKMWDYLRL
LLERWQYGL

3D structure

• PDB: 3x0v Recombinant expression, molecular characterization and crystal structure of antitumor enzyme, l-lysine alpha-oxidase from Trichoderma viride.
• Chain: A
• Resolution: 1.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D212 K319
• Catalytic site (residue number reindexed from 1): D209 K316
• Enzyme Commision number: 1.4.3.14: L-lysine oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	V13 G14 G16 V17 S18 E40 S41 G47 R48 G65 A66 M67 R68 Y69 R251 V252 T286 C290 S317 W429 N434 A438 F439 E468 A475 W476 I477 S480	V10 G11 G13 V14 S15 E37 S38 G44 R45 G62 A63 M64 R65 Y66 R248 V249 T283 C287 S314 W426 N431 A435 F436 E465 A472 W473 I474 S477

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0001716 L-amino-acid oxidase activity
• GO:0016491 oxidoreductase activity
• GO:0050029 L-lysine oxidase activity

Biological Process

• GO:0009063 amino acid catabolic process

External links

• PDB: RCSB:3x0v, PDBe:3x0v, PDBj:3x0v
• PDBsum: 3x0v
• PubMed: 25648943
• UniProt: A0A0J9X1X3