Structure of PDB 3wxa Chain A

Receptor sequence
>3wxaA (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
QSFLWNVFQRVDKDRSGVISDTELQQALSNGTWTPFNPVTVRSIISMFDR
ENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGFGY
RLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDG
WIQVSYEQYLSMVFSIV
3D structure
PDB3wxa Structural Analysis of the Complex between Penta-EF-Hand ALG-2 Protein and Sec31A Peptide Reveals a Novel Target Recognition Mechanism of ALG-2
ChainA
Resolution2.36 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F85 G108 I110
Catalytic site (residue number reindexed from 1) F61 G84 I86
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V31 L48 A51 L52 S53 G55 W57 F85 I92 Q96 F148 V7 L24 A27 L28 S29 G31 W33 F61 I68 Q72 F124
BS02 ZN A D36 D38 V42 E47 D12 D14 V18 E23
BS03 ZN A D105 M109 E114 D81 M85 E90
BS04 ZN A D105 D111 D81 D87
BS05 ZN A D171 D173 D147 D149
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0030674 protein-macromolecule adaptor activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043495 protein-membrane adaptor activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0048306 calcium-dependent protein binding
GO:1990756 ubiquitin-like ligase-substrate adaptor activity
Biological Process
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0006886 intracellular protein transport
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0006915 apoptotic process
GO:0010595 positive regulation of endothelial cell migration
GO:0014029 neural crest formation
GO:0014032 neural crest cell development
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007 negative regulation of TOR signaling
GO:0034605 cellular response to heat
GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045766 positive regulation of angiogenesis
GO:0048208 COPII vesicle coating
GO:0051592 response to calcium ion
GO:0051898 negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0097190 apoptotic signaling pathway
GO:1902527 positive regulation of protein monoubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0030127 COPII vesicle coat
GO:0031410 cytoplasmic vesicle
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0070971 endoplasmic reticulum exit site

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wxa, PDBe:3wxa, PDBj:3wxa
PDBsum3wxa
PubMed25667979
UniProtO75340|PDCD6_HUMAN Programmed cell death protein 6 (Gene Name=PDCD6)

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